一般认为微量元素含量的失衡可导致DNA的不稳定  ，从而构成了癌症发生的前提条件 。有研究发现  ，在锰（甘氨酸锰Manganese Glycinate、抗坏血酸锰Manganese Ascorbate）缺失的小鼠体内肿瘤细胞的生长和肿瘤肺转移显著增强  ，肿瘤浸润的CD8+T细胞明显减少  ，表明锰元素（甘氨酸锰Manganese Glycinate、抗坏血酸锰Manganese Ascorbate）不足可能导致肿瘤加速增长  ，其在抑制肿瘤的发生发展中可能发挥至关重要作用  ，研究发现  ，在胃癌细胞AGS、BGC-823中添加锰离子（甘氨酸锰Manganese Glycinate、抗坏血酸锰Manganese Ascorbate）  ，发现可增强牛乳铁蛋白水解物的抗癌效果  ，使其具有更强的生长抑制作用  ，并促进细胞凋亡   ，同时导致更多的细胞被阻滞在G0/G1期 。还有研究表明  ，锰（甘氨酸锰Manganese Glycinate、抗坏血酸锰Manganese Ascorbate）可以通过激活细胞caspase-3途径和caspase-12途径诱导宫颈癌细胞HeLa和小鼠胚胎成纤维细胞NIH3T3细胞凋亡；在肝癌Huh7和HepG2.2.15细胞中也观察到锰离子（甘氨酸锰Manganese Glycinate、抗坏血酸锰Manganese Ascorbate）在多个浓度下均能抑制肝癌细胞增殖活力及克隆形成  ，并促进细胞凋亡  ，而且随着锰离子（甘氨酸锰Manganese Glycinate、抗坏血酸锰Manganese Ascorbate）溶液浓度的增大  ，细胞增殖活力及克隆形成能力随之降低  ，而凋亡率随之增大  ，说明锰离子（甘氨酸锰Manganese Glycinate、抗坏血酸锰Manganese Ascorbate）对肝癌细胞的抑制作用具有剂量依赖性  ，且肿瘤微BB贝博艾弗森官方网站中低浓度的锰可能更有利于肝癌的发生发展 。

锰离子（甘氨酸锰Manganese Glycinate、抗坏血酸锰Manganese Ascorbate）对肝癌细胞增殖及凋亡的影响

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抗坏血酸锰Manganese Ascorbate、抗坏血酸亚铁Ferrous Ascorbate、赖氨酸甘氨酸镁Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺镁Magnesium Glycinate Glutamine、柠檬酸苹果酸镁Magnesium Citrate Malate、柠檬酸锶Strontium Citrate、柠檬酸锰Manganese Citrate、柠檬酸铜Copper Citrate、天门冬氨酸锂Lithium Aspartate、牛磺酸硒Selenium Taurate.

Effect of manganese ions (Manganese glycinate, Manganese ascorbate) on the proliferation and apoptosis of hepatocellular carcinoma cells

It is generally believed that an imbalance in trace element content can lead to DNA instability, which constitutes a prerequisite for the occurrence of cancer. It has been found that the growth of tumor cells and tumor lung metastasis in mice with manganese (manganese glycinate, manganese ascorbate) deletion are significantly enhanced, and the CD8+ T cells infiltrated by tumors are significantly reduced, indicating that insufficient manganese (manganese glycinate, manganese ascorbate) may lead to accelerated tumor growth. It may play a crucial role in inhibiting the occurrence and development of tumors, and studies have found that adding manganese ions (Manganese glycinate, Manganese ascorbate) to gastric cancer cells AGS and BGC-823 has been found to enhance the anti-cancer effect of bovine lactoferrin hydrolysate, making it have a stronger growth inhibitory effect, and promote apoptosis, while causing more cells to be arrested in the G0/G1 phase. Other studies have shown that manganese (Manganese glycinate, Manganese ascorbate) can induce apoptosis of cervical cancer cells HeLa and mouse embryonic fibroblasts NIH3T3 cells by activating the cellular caspase-3 pathway and caspase-12 pathway. In HCC Huh7 and HepG2.2.15 cells, manganese ions (Manganese glycinate, Manganese ascorbate) were also observed to inhibit the proliferation and clonal formation of HCC cells and promote apoptosis at multiple concentrations Ascorbate) solution decreased the cell proliferation activity and clone formation ability, and the apoptosis rate increased, indicating that the inhibitory effect of manganese ions (Manganese glycinate, manganese ascorbate) on hepatocellular carcinoma cells was dose-dependent, and low concentrations of manganese in the tumor microenvironment may be more conducive to the occurrence and development of hepatocellular carcinoma.

Effect of manganese ions (Manganese glycinate, Manganese ascorbate) on the proliferation and apoptosis of hepatocellular carcinoma cells

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Manganese Ascorbate, Ferrous Ascorbate, Magnesium Lysinate Glycinate, Magnesium Glycinate Glutamine, Magnesium Citrate Malate, Strontium Citrate, Manganese Citrate, Copper Citrate, Lithium Aspartate, Selenium Taurate.