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影响多肽与亚铁螯合能力的关键因素

撤稿時间:2025-01-22 19:21

调查找到多肽的有机酸等形成、分布、团伙量等引响  ,均会引响其亚铁螯合本事  ,至少有机酸等形成和分布是最终要的引响引响 。似的来说一  ,包括亚铁阳阴阳阴阳离子螯合活性酶类的多肽居多有半胱氨酸、组氨酸、丝氨酸、天冬氨酸和谷氨酸等有机酸等 。多肽的团伙量是引响螯合的性能和稳定的性的重要性引响 。越发愈多的调查表示低团伙量的多肽与亚铁阳阴阳阴阳离子包括极高的螯合本事 。调查找到  ,那些有机酸等与亚铁阳阴阳阴阳离子的螯合本事是有机酸等上的特殊性基团取决于的 。当或者有机酸等残基应用于 N-端部或 C-后部时  ,多肽的亚铁螯合活性酶被 改善  ,地属 N-末的组氨酸残基多肽的铝合金螯合力比最靠近 C-末商品详情页强 。含酸性核苷酸、典型的含碱核苷酸和些特别核苷酸对亚铁铝离子有比较强的螯合力量 。诸如  ,组氨酸和谷氨酸各自以咪唑环、 γ-COO-给出了更好的铁相结合位点  ,才能有着好的螯合技能 。

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抗坏血酸亚铁Ferrous Ascorbate、赖氨酸甘氨酸镁Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺镁Magnesium Glycinate Glutamine、柠檬片酸草莓酸镁Magnesium Citrate Malate、柚子酸锶Strontium Citrate、柠檬片酸锰Manganese Citrate、柠檬百香果酸铜Copper Citrate、天门冬氨酸锂Lithium Aspartate、抗坏血酸锰Manganese Ascorbate、牛磺酸硒Selenium Taurate 。

The key factors influencing the chelating ability of polypeptides to ferrous

Studies have shown that the amino acid composition, arrangement and molecular weight of polypeptides can affect their ferrous chelating ability, among which the amino acid composition and arrangement are the most important factors. In general, polypeptides with ferrous ion chelating activity mostly contain amino acids such as cysteine, histidine, serine, aspartate and glutamic acid. The molecular weight of peptides is an important factor affecting the chelation performance and stability. More and more studies have shown that low molecular weight polypeptides have higher chelation ability with ferrous ions. It has been found that the chelating ability of some amino acids with ferrous ions is determined by special groups on amino acids. When some amino acid residues are located at the N-terminal or C-terminal, the ferrous chelating activity of the polypeptide is enhanced, and the metal chelating ability of the histidine residues in the n-terminal is stronger than that in the C-terminal. Acidic amino acids, basic amino acids and some special amino acids have strong chelating ability to ferrous ions. For example, histidine and glutamate provide more iron-binding sites in imidazole ring and gamma-COO -, respectively, and thus have better chelating ability.

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Ferrous Ascorbate, Magnesium Lysinate Glycinate, Magnesium lysinate Glycinate Glutamine, Magnesium citrate malate Citrate Malate, Strontium Citrate, Manganese Citrate, Copper Citrate, Lithium Aspartate, Manganese ascorbate Ascorbate, Selenium Taurate.